ea0029p615 | Diabetes | ICEECE2012
Kravchuk E.
, Grineva E.
, Galagudza M.
, Kostareva A.
Introduction: The aim of our experimental study was to investigate the effect of both T2DM and metformin treatment on myocardial tolerance to ischemia-reperfusion injury and cardiac AMP-activated protein kinase (AMPK) activity.Methods: The protocol included four groups: i) controls (n=13) non-diabetic rats treated with i.p. vehicle injections for 3 days prior to the heart perfusion, ii) controls+metformin (CM; n=12) non-diabet...